Melvin Receives $500K NSF Grant for Cancer, Diabetes Research
March 27, 2019
BATON ROUGE, LA 鈥� The National Science Foundation recently awarded 海角社区 Assistant Professor
of Chemical Engineering Adam Melvin a $500,004 grant as part of its Faculty Early
Career Development (CAREER) Program for his work on developing new peptides to control
protein degradation, which can be used in diagnosing cancer and diabetes.
One central control system for protein degradation in cells is referred to as the UPS, or ubiquitin-proteasome system. The activity of the enzymes in the UPS, like the proteasome, is highly variable across individual cells in a population; therefore, it is important to be able to measure proteasome activity on a single-cell basis. Melvin鈥檚 project will develop fluorescent sensors to do just that.
These sensors could enhance efforts to develop new drugs and optimize treatment strategies on a patient-by-patient basis. As part of this project, Melvin is also designing new peptides to selectively target so-called 鈥渦ndruggable鈥� proteins to proteasome as a new approach in diabetes in obesity-related therapeutics. Hands-on learning modules will also be developed and presented to middle school students in the Baton Rouge area; and undergraduate and high school students will be recruited to participate in extended research experiences in an effort to develop and populate a robust biomanufacturing workforce.
Melvin has been part of the 海角社区 Cain Department of Chemical Engineering鈥檚 faculty since 2013. He earned both his master鈥檚 and PhD in chemical engineering from North Carolina State University.
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